RNA Details
Disease Name
silicosis
Tissue
lung
RNA Symbol
miR-205-5p
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
Immunohistochemistry; qRT-PCR; Western Blot etc.
Target
E2f1
Pathway
NA
PubMed ID
Title
MicroRNA-205-5p targets E2F1 to promote autophagy and inhibit pulmonary fibrosis in silicosis through impairing SKP2-mediated Beclin1 ubiquitination
Year
2021
Function
The quantitative analysis of miRNAs in the mouse silicosis tissues identified that only the miR-205-5p expression pattern was significantly downregulated in the alveolar tissues of silicosis.